This activity uses a simulation from the Concord Consortium that shows how DNA is transcribed to RNA and then turned into a protein. It’s a very clear animation and can be used on its own as part of a lecture on protein synthesis.
The simulation then allows you to edit the DNA which will then create a new protein. The worksheet asks students to review terms and label an image showing tRNA, mRNA, codons, amino acids, and ribosomes.
Students then edit the DNA in a specific way so that they can observe the effects of a point mutation, a frameshift mutation, and a silent mutation. In the point mutation, a single base is changed which leads to a difference amino acid. Students do not need a codon chart to complete this activity.
You can also do this activity with the class if you have a projector, this would also allow more discussion on why some point mutations change the output protein and why some are silent.
Grade Level: 10-12
Time Required: 15-20 minutes
Download PDF Google Doc Key (TpT)
HS-LS1-1 Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells
HS-LS3-1 Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring.
Abigail A King
Do you have a teacher key for the worksheet included with this activity?
It would be much appreciated.
Thank you,
Abigail King
Admin
I do not have one made, but I will put it on my to-do list.
Cindi Husting
The simulation does not work…load up. Anybody know why?
Admin
I checked just now, it loaded for me. I’m using a chrome browser.
Sharlene Haeger
FYI, there’s a big mistake in the directions for #4, 6, and 7. It says to change the ‘codon’ in the DNA. There are no codons in DNA, they’re triplets. Codons are only in mRNA. Please correct this. It caused confusion for my students when they complete this worksheet for homework.
Admin
Thank you for bringing this to my attention. I will correct it right away!
heather
Are you having any problems with the link to the Concord site? I did this last year but it’s not working now.
Admin
I’ve been having trouble all week with sites, I think networks are overloaded due to Covid-19.
Grace
Do you have an answer key?
Admin
There is one up at TpT: https://www.teacherspayteachers.com/Product/DNA-Mutation-Activity-KEY-5344465