Name:_________________________________

## Anatomy & Physiology - Genetics of Blood Disorders

SHOW ALL WORK!

1. If a female is a carrier for hemophilia X ^{H} X ^{h} and is married to a man with hemophilia X ^{h} Y , what is the probability that she will have a daughter with hemophilia? _____

2. A normal female X ^{H} X ^{H }marries a man who has hemophilia.

What percentage of their sons will have hemophilia? _______

3. If a female has hemophilia and is married to a normal man....

What percentage of her sons will have hemophilia? ______

What percentage of her daughters will have hemophilia? _______

4. A woman with sickle cell anemia is married to a man who is a carrier for the trait **( a a x A a)**.

What is the chance of their children having sickle cell anemia? _____

5. What is the probability that two people who are both being carriers for sickle cell anemia will have a child with the disease? ____

6, What is the chance that a female who is a carrier for sickle cell anemia will have a child with sickle cell anemia if she marries a normal man?

7. Von Willebrand Disease is an autosomal dominant disorder (not located on the sex chromosomes) where blood will not clot properly.

What would be the two possible __genotypes__ of a person who has the disorder?

If a person is heterozygous for the trait (having the disease) is married to a normal spouse (dd), what is the chance that their children will have the disorder.