Activity: Construct a DNA Model

Instructions

1. Cut out each of the nucleotides (used the dash lines as a guide) and arrange them on the grid. Remember the Base-Pair Rule. (You will have one set left over). Separate paper may also be used.

2. In order to match the pairs, one of the nucleotides must be arranged upside down. This is intended. The sides of the DNA double helix are arranged in an anti-parallel fashion. Think of them like lanes on a highway going different directions.

3. Color each of the nucleotides

Thymine = orange | Adenine = green
Guanine = purple | Cytosine = yellow
Deoxyribose = blue
Phosphate = pink

Questions:

1. Describe the base-pair rule.

2. What three things make up a nucleotide?

3. What does anti-parallel mean?

Other Resources on DNA

DNA Extraction for Freshman - a simpler version of this activity, uses only strawberry

Coloring DNA – basic image of DNA and RNA for students to color following directions; includes questions and analysis

Transcription & Translation Coloring - shows structures involved, nucleotides, base pair rules, amino acids

DNA Concept Map - design a concept map showcasing the structure and function of DNA

DNA Models - students can examine 3D models of DNA to understand the structure