14-3 Human Molecular Genetics

HUMAN DNA ANALYSIS

DNA Fingerprinting:
" Genetically, every individual is uniquely different (except identical twins)
" Analyzes sections of DNA (fig 14-18)
" Uses gel electrophoresis
" DNA samples from blood, sperm, hair, saliva,…

THE HUMAN GENOME PROJECT 1990 ' 2000
Searching For Genes:
*Only a small part of the human genome is actual working genes. ~25,000 genes

Why look for genes?
1) may provide clues to the basic properties of life
2) how genes may have commercial value
3) development of drugs or treatment for diseases


GENE THERAPY
* Faulty gene replaced by a normal gene
* Potential to cure disorders (cystic fibrosis)
* Uses viruses to insert DNA (see Figure 14-21, p 360)

ETHICAL ISSUES IN HUMAN GENETICS

To cure genetic diseases (CF, Tay-Sachs,
Hemophilia)
What about dwarfism?

Design our bodies (pick hair color, height, and blood type)

Clone our bodies, pets, livestock